Identification of key cytosolic kinases containing evolutionarily conserved kinase tyrosine-based inhibitory motifs (KTIMs)

We previously reported that SHP-1 regulates IRAK-1 activity by binding to an ITIM-like motif found within its kinase domain, which we named kinase tyrosine-based inhibitory motif (KTIM). Herein, we further investigated the presence, number, location, and evolutionary time of emergence of potential K...

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Bibliographic Details
Published in:	Developmental and comparative immunology 2010-05, Vol.34 (5), p.481-484
Main Authors:	Abu-Dayyeh, Issa, Ralph, Benjamin, Grayfer, Leon, Belosevic, Miodrag, Cousineau, Benoit, Olivier, Martin
Format:	Article
Language:	English
Subjects:	Amino Acid Motifs - genetics Animals Catalytic Domain - genetics Cell Line, Transformed Conserved Sequence - genetics Cytosol - immunology Drosophila melanogaster Evolution, Molecular Goldfish Humans Immunity, Innate Innate immunity ITIM Kinase KTIM Macrophages - immunology Macrophages - metabolism Macrophages - pathology Mice Protein Kinases - genetics Protein Kinases - immunology Protein Kinases - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism Sequence Alignment Sequence Analysis, Protein SHP-1 Signal Transduction - genetics Signal Transduction - immunology Signalling Tyrosine - genetics Tyrosine - metabolism Vertebrates
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