Radio frequency rectification on membrane bound pores

Probing the interaction of biological systems with radio frequencies holds great promise for research and drug screening applications. While a common assumption is that biological systems do not operate at radio frequencies, we find that currents due to ion transport through channels and pores in ce...

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Bibliographic Details
Published in:Nanotechnology 2010-02, Vol.21 (7), p.075201-075201
Main Authors: Ramachandran, Sujatha, Blick, Robert H, van der Weide, Daniel W
Format: Article
Language:English
Subjects:
Alamethicin - metabolism
Biological
Cell Membrane - physiology
Channels
Electromagnetic Fields
Fungal Proteins - metabolism
Hemolysin Proteins - metabolism
Ion channels
Ion Channels - physiology
Ion transport
Lipid Bilayers
Membranes
Models, Biological
Modulation
Porosity
Radio frequencies
Radio Waves
Rectification
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Summary:Probing the interaction of biological systems with radio frequencies holds great promise for research and drug screening applications. While a common assumption is that biological systems do not operate at radio frequencies, we find that currents due to ion transport through channels and pores in cell membranes are in the pA to nA range. These values translate via the average current I = ne/tau(d) = nef to frequencies in the range of 1 MHz-1 GHz, where n is the average number of ions transported and tau(d) is the dwell time of the ions in the channel. It is thus desirable to have circuitry available which facilitates radio frequency spectroscopy of ion transport. This will yield real-time in vitro information on ion channel operation. Here we present measurements on the local interaction of a radio frequency signal with single ion channels and pores. We find radio frequency rectification and pumping on the channels and pores embedded in suspended bilipid membranes, recorded in direct current measurements. This electromagnetic modulation can be used to probe the dynamics of ion channel conformational changes.
ISSN:0957-4484
1361-6528
DOI:10.1088/0957-4484/21/7/075201