Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy: A Randomized Clinical Trial

CONTEXT Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department. OBJECTIVE To test the hypothesis of noninferiority between lactate clearance and central venous oxygen saturation (ScvO2) as goals of early sepsis re...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2010-02, Vol.303 (8), p.739-746
Main Authors: Jones, Alan E, Shapiro, Nathan I, Trzeciak, Stephen, Arnold, Ryan C, Claremont, Heather A, Kline, Jeffrey A, Emergency Medicine Shock Research Network (EMShockNet) Investigators, for the
Format: Article
Language:English
Subjects:
Adult
Aged
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Cardiotonic Agents - therapeutic use
Central Venous Pressure
Disease management
Dobutamine - therapeutic use
Emergency medical care
Erythrocyte Transfusion
Female
Fluid Therapy
General aspects
Hospital Mortality
Human bacterial diseases
Humans
Infectious diseases
Lactic Acid - blood
Lactic Acid - metabolism
Male
Medical sciences
Medical treatment
Middle Aged
Mortality
Oxygen - blood
Prospective Studies
Sepsis
Sepsis - blood
Sepsis - mortality
Sepsis - therapy
Shock, Septic - blood
Shock, Septic - mortality
Shock, Septic - therapy
Treatment Outcome
Vasoconstrictor Agents - administration & dosage
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