Class I antiarrhythmic drugs: mechanisms, contraindications, and current indications

Class I antiarrhythmic drugs are sodium channel inhibitors that act by slowing myocardial conduction and, thus, interrupting or preventing reentrant arrhythmia. Due to proarrhythmic effects and the risk of ventricular tachyarrhythmia, class I antiarrhythmics should not be administered in patients wi...

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Bibliographic Details
Published in:Herzschrittmachertherapie & Elektrophysiologie 2010-12, Vol.21 (4), p.228
Main Authors: Pott, C, Dechering, D G, Muszynski, A, Zellerhoff, S, Bittner, A, Wasmer, K, Mönnig, G, Eckardt, L
Format: Article
Language:ger
Subjects:
Administration, Oral
Adrenergic beta-Antagonists - therapeutic use
Anti-Arrhythmia Agents - adverse effects
Anti-Arrhythmia Agents - classification
Anti-Arrhythmia Agents - therapeutic use
Arrhythmias, Cardiac - chemically induced
Arrhythmias, Cardiac - drug therapy
Arrhythmias, Cardiac - mortality
Atrial Fibrillation - drug therapy
Atrial Fibrillation - mortality
Contraindications
Dose-Response Relationship, Drug
Drug Therapy, Combination
Electrocardiography - drug effects
Female
Heart Failure - complications
Heart Failure - drug therapy
Humans
Infusions, Intravenous
Myocardial Infarction - complications
Myocardial Infarction - drug therapy
Pregnancy
Randomized Controlled Trials as Topic
Sodium Channel Blockers - adverse effects
Sodium Channel Blockers - classification
Sodium Channel Blockers - therapeutic use
Tachycardia, Atrioventricular Nodal Reentry - drug therapy
Tachycardia, Supraventricular - drug therapy
Tachycardia, Ventricular - drug therapy
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Summary:Class I antiarrhythmic drugs are sodium channel inhibitors that act by slowing myocardial conduction and, thus, interrupting or preventing reentrant arrhythmia. Due to proarrhythmic effects and the risk of ventricular tachyarrhythmia, class I antiarrhythmics should not be administered in patients with structural heart disease. Nevertheless, there remains a broad spectrum of arrhythmias--among the most common being atrial fibrillation--that can successfully be treated with class I antiarrhythmic drugs. This review gives an overview on the classification, antiarrhythmic mechanisms, indications, side effects, and application modes of class I antiarrhythmic drugs.
ISSN:1435-1544