Determinants and Risk Factors for Central Corneal Thickness in Japanese Persons: The Funagata Study

Purpose: To examine the association between glucose metabolism and central corneal thickness (CCT) in Japanese adults. Methods: A sub-sample of 322 Japanese adults participating in the Funagata Study was included in this analysis. CCT was measured using a specular microscope. Glucose metabolism was...

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Bibliographic Details
Published in:Ophthalmic epidemiology 2011-10, Vol.18 (5), p.244-249
Main Authors: Nishitsuka, Koichi, Kawasaki, Ryo, Kanno, Makoto, Tanabe, Yusuke, Saito, Koko, Honma, Kei, Oizumi, Toshihide, Daimon, Makoto, Kato, Takeo, Kayama, Takamasa, Yamashita, Hidetoshi
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Glucose - metabolism
Central corneal thickness
Cornea - anatomy & histology
Diabetes Mellitus - physiopathology
Female
Glucose Intolerance - physiopathology
Glucose metabolism
Glucose Tolerance Test
Glycated Hemoglobin A - analysis
Humans
Japan
Male
Middle Aged
Multivariate Analysis
Obesity
Risk Factors
Smoking
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Summary:Purpose: To examine the association between glucose metabolism and central corneal thickness (CCT) in Japanese adults. Methods: A sub-sample of 322 Japanese adults participating in the Funagata Study was included in this analysis. CCT was measured using a specular microscope. Glucose metabolism was examined using 75-g oral glucose tolerance test. Mean differences in CCT (μm) and 95% confidence intervals were estimated with univariate, age-sex-adjusted and multivariate models using multiple linear regression. Results: The mean (± standard deviation) age of the study sample was 63.7 ± 11.4 years and 44% were men. The mean fasting plasma glucose (FPG), 2-hour post-load plasma glucose (2hPG) and haemoglobin A1c (HbA1c) concentrations were 96.8 ± 12.6mg/dl, 123.6 ± 41.2mg/dl and 5.3 ± 0.4%, respectively. CCT was normally distributed in the study sample, and the mean CCT was 544.7 ± 34.6μm. After multivariate adjustment, characteristics associated with increased CCT were 2hPG and HbA1c concentrations, impaired glucose tolerance, diabetes, body weight or body mass index and current smoking. Conclusion: Impaired glucose tolerance, diabetes, obesity and current smoking are associated with increased CCT. Additional studies are required to examine whether interventions to affect these characteristics may reduce CCT.
ISSN:0928-6586
1744-5086
DOI:10.3109/09286586.2011.594206