How CD95 stimulates invasion

CD95 is best known for its capacity to induce apoptosis, but also activates multiple non-apoptotic signalling pathways. In particular, CD95 promotes migration and tissue invasion of apoptosis-resistant cell types, and this plays a central role in inflammation, neurobiology, and tumor biology. CD95 i...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2011-11, Vol.10 (22), p.3857-3862
Main Authors: Steller, Ernst J.A., Borel Rinkes, Inne H.M., Kranenburg, Onno
Format: Article
Language:English
Subjects:
Actin Cytoskeleton - metabolism
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cell Line, Tumor
Cell Movement
Cycle
Enzyme Activation
Extracellular Matrix - metabolism
fas Receptor - genetics
fas Receptor - metabolism
fas Receptor - physiology
Focal Adhesions - metabolism
Humans
Integrins - metabolism
Landes
Models, Biological
Neoplasms - metabolism
Neoplasms - pathology
Organogenesis
Protein-Tyrosine Kinases - metabolism
Proteins
rac GTP-Binding Proteins - metabolism
Signal Transduction
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Summary:CD95 is best known for its capacity to induce apoptosis, but also activates multiple non-apoptotic signalling pathways. In particular, CD95 promotes migration and tissue invasion of apoptosis-resistant cell types, and this plays a central role in inflammation, neurobiology, and tumor biology. CD95 induces invasion by stimulating the expression of extracellular matrix (ECM)-degrading proteases, and by stimulating the formation of actin-driven cell protrusions through Rac and the cofilin pathway. In this review we discuss how CD95-initiated signalling pathways may cooperate to facilitate cell migration and tissue invasion. -
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.10.22.18290