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How CD95 stimulates invasion

CD95 is best known for its capacity to induce apoptosis, but also activates multiple non-apoptotic signalling pathways. In particular, CD95 promotes migration and tissue invasion of apoptosis-resistant cell types, and this plays a central role in inflammation, neurobiology, and tumor biology. CD95 i...

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Published in:	Cell cycle (Georgetown, Tex.) Tex.), 2011-11, Vol.10 (22), p.3857-3862
Main Authors:	Steller, Ernst J.A., Borel Rinkes, Inne H.M., Kranenburg, Onno
Format:	Article
Language:	English
Subjects:	Actin Cytoskeleton - metabolism Binding Biology Bioscience Calcium Cancer Cell Cell Line, Tumor Cell Movement Cycle Enzyme Activation Extracellular Matrix - metabolism fas Receptor - genetics fas Receptor - metabolism fas Receptor - physiology Focal Adhesions - metabolism Humans Integrins - metabolism Landes Models, Biological Neoplasms - metabolism Neoplasms - pathology Organogenesis Protein-Tyrosine Kinases - metabolism Proteins rac GTP-Binding Proteins - metabolism Signal Transduction
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container_issue	22
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creator	Steller, Ernst J.A. Borel Rinkes, Inne H.M. Kranenburg, Onno
description	CD95 is best known for its capacity to induce apoptosis, but also activates multiple non-apoptotic signalling pathways. In particular, CD95 promotes migration and tissue invasion of apoptosis-resistant cell types, and this plays a central role in inflammation, neurobiology, and tumor biology. CD95 induces invasion by stimulating the expression of extracellular matrix (ECM)-degrading proteases, and by stimulating the formation of actin-driven cell protrusions through Rac and the cofilin pathway. In this review we discuss how CD95-initiated signalling pathways may cooperate to facilitate cell migration and tissue invasion. -
doi_str_mv	10.4161/cc.10.22.18290
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subjects	Actin Cytoskeleton - metabolism Binding Biology Bioscience Calcium Cancer Cell Cell Line, Tumor Cell Movement Cycle Enzyme Activation Extracellular Matrix - metabolism fas Receptor - genetics fas Receptor - metabolism fas Receptor - physiology Focal Adhesions - metabolism Humans Integrins - metabolism Landes Models, Biological Neoplasms - metabolism Neoplasms - pathology Organogenesis Protein-Tyrosine Kinases - metabolism Proteins rac GTP-Binding Proteins - metabolism Signal Transduction
title	How CD95 stimulates invasion
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