Regulation of NF-κB by deubiquitinases

The nuclear factor‐κB (NF‐κB) pathway is a critical regulator of innate and adaptive immunity. Noncanonical K63‐linked polyubiquitination plays a key regulatory role in NF‐κB signaling pathways by functioning as a scaffold to recruit kinase complexes containing ubiquitin‐binding domains. Ubiquitinat...

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Bibliographic Details
Published in:	Immunological reviews 2012-03, Vol.246 (1), p.107-124
Main Authors:	Harhaj, Edward W., Dixit, Vishva M.
Format:	Article
Language:	English
Subjects:	A20 Adaptive Immunity Animals Cancer CYLD deubiquitinases Endopeptidases - metabolism Humans Immunity Immunity, Innate inflammation Inflammation - immunology Inflammation - metabolism Inflammatory diseases Intracellular Signaling Peptides and Proteins - metabolism Neoplasms - immunology Neoplasms - metabolism NF- Kappa B protein NF-kappa B - metabolism NF-κB proteasomes Protein Binding Recruitment scaffolds Signal Transduction Tumor Suppressor Proteins - metabolism Ubiquitin Ubiquitin-protein ligase Ubiquitination
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