The long view: a selective review of 40 years of Newcastle disease research

This review is written for the series celebrating the 40th year since the first issue of Avian Pathology. The aim of the authors was to cover the developments in Newcastle disease (ND) research over the last 40 years that they considered significant. During those 40 years there have been several pan...

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Bibliographic Details
Published in:Avian pathology 2012-08, Vol.41 (4), p.329-335
Main Authors: Alexander, Dennis J., Aldous, Elizabeth W., Fuller, Chad M.
Format: Article
Language:English
Subjects:
Animals
Birds
Genome, Viral - genetics
Humans
Newcastle Disease - diagnosis
Newcastle Disease - epidemiology
Newcastle Disease - virology
Newcastle disease virus - classification
Newcastle disease virus - genetics
Newcastle disease virus - pathogenicity
Pandemics - veterinary
Phylogeny
Poultry
Poultry Diseases - diagnosis
Poultry Diseases - epidemiology
Poultry Diseases - virology
Virulence - genetics
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Summary:This review is written for the series celebrating the 40th year since the first issue of Avian Pathology. The aim of the authors was to cover the developments in Newcastle disease (ND) research over the last 40 years that they considered significant. During those 40 years there have been several panzootics of this serious disease in poultry and for the last 30 years there has been a continuing panzootic in domestic pigeons, which has spread to wild birds and poultry. The 40-year period began with worldwide outbreaks of severe ND, which served as an important impetus for ND research work. Although early work was concerned with controlling the disease, specifically by improving and developing new vaccines and vaccine regimens, even prior to the 1970s ND virus was seen as a useful laboratory virus for replication and virulence studies. This review covers the historical developments in the following areas: understanding the molecular basis of virulence; epidemiology and relatedness of different ND strains, both antigenically and genetically; the emergence of virulent strains and their relationship with viruses of low virulence; sequencing and understanding the viral genome and genes; the development of rapid molecular-based diagnostic tests; and the phylogeny and molecular taxonomy of ND virus. The authors suggest areas in which future research could or should be undertaken.
ISSN:0307-9457
1465-3338
DOI:10.1080/03079457.2012.697991