New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation

Novel 2,3-diaminopropionic acid-based molecules were synthesised and tested successfully as glyoxal/methylglyoxal scavengers and as AGE inhibitors. Addition of an 8-hydroxyquinoline moiety led to an increase of the overall activity. The compounds tested in this study were also proved to be efficient...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2013-02, Vol.11 (5), p.773-78
Main Authors: Audic, Nicolas, Potier, Guy, Sasaki, N. André
Format: Article
Language:English
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Summary:Novel 2,3-diaminopropionic acid-based molecules were synthesised and tested successfully as glyoxal/methylglyoxal scavengers and as AGE inhibitors. Addition of an 8-hydroxyquinoline moiety led to an increase of the overall activity. The compounds tested in this study were also proved to be efficient in trapping ALE precursor malondialdehyde. Novel 2,3-diaminopropionic acid-based molecules were synthesised and tested successfully as glyoxal/methylglyoxal scavengers and as AGE inhibitors. Addition of an 8-hydroxyquinoline moiety led to an increase of the overall activity. The compounds tested in this study were also proved to be efficient in trapping ALE precursor malondialdehyde.
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob27084f