Leukemic Stem Cells: A Review

A small subset of cells in a patient with leukemia, termed leukemic stem cells (LSCs) have been shown to be responsible for the proliferation of disease. LSCs are thought to derive from normal hematopoietic stem cells, but are phenotypically distinguishable in that they are CD90-, CD117-, and CD123+...

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Bibliographic Details
Published in:Cancer investigation 2013-05, Vol.31 (4), p.215-220
Main Authors: O'Brien, J. A., Rizzieri, D. A.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Hematologic and hematopoietic diseases
Hematopoietic Stem Cells - pathology
Humans
Keywords: Leukemia
Leukemia - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukemic stem cells
Medical sciences
Neoplastic Stem Cells - pathology
Pharmacology. Drug treatments
Stem cell therapy
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Summary:A small subset of cells in a patient with leukemia, termed leukemic stem cells (LSCs) have been shown to be responsible for the proliferation of disease. LSCs are thought to derive from normal hematopoietic stem cells, but are phenotypically distinguishable in that they are CD90-, CD117-, and CD123+. Research in mouse models provides several potential therapeutics to target these cells in human patients. Eliminating LSCs should provide an efficient, potentially curative treatment option for leukemia patients.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2012.700986