Physicochemical and structural characterization of iron-sucrose formulations: a comparative study

Abstract Intravenous polynuclear iron formulations are vital components in the treatment of iron deficiency anemia associated with chronic kidney disease as well as other diseases associated with gastro-intestinal and cardio-vascular system. Intravenous iron preparations consist of iron-carbohydrate...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2014-08, Vol.19 (5), p.513-520
Main Authors: Barot, Bhavesh S., Parejiya, Punit B., Mehta, Dharmik M., Shelat, Pragna K., Shah, Gaurang B.
Format: Article
Language:English
Subjects:
Anemia, Iron-Deficiency - drug therapy
Chromatography, Gel
Ferric Compounds - chemistry
Fourier transform infrared spectroscopy
gel permeation chromatography
Glucaric Acid - chemistry
Humans
iron-sucrose
Magnetic Resonance Spectroscopy
mass spectroscopy
nuclear magnetic resonance spectroscopy
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Spectroscopy, Fourier Transform Infrared
Sucrose - chemistry
Venofer
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Summary:Abstract Intravenous polynuclear iron formulations are vital components in the treatment of iron deficiency anemia associated with chronic kidney disease as well as other diseases associated with gastro-intestinal and cardio-vascular system. Intravenous iron preparations consist of iron-carbohydrate nanoparticles with iron-oxyhydroxide as a core covered by carbohydrate shell. These preparations should be very well characterized in terms of their physicochemical properties and pharmacological profile in order to establish safety and efficacy. The present research work was aimed to physicochemically characterize a new generic iron-sucrose preparation (IS-Claris) and establish its equivalency with the reference product (Venofer®). Various analytical techniques including gel permeation chromatography (GPC), mass spectroscopy (MALDI-TOF), absorption spectroscopy, X-ray diffraction analysis (XRD), nuclear magnetic resonance spectroscopy (proton and 13C NMR), Fourier transform infrared spectroscopy (FTIR) and thermal gravimetric analysis (TGA) were employed. It was observed that the specifications of IS-Claris obtained through these analyses reflect those of Venofer® and hence the two formulations were considered comparable.
ISSN:1083-7450
1097-9867
DOI:10.3109/10837450.2013.795171