Sclerostin Regulates Release of Bone Mineral by Osteocytes by Induction of Carbonic Anhydrase 2

The osteocyte product sclerostin is emerging as an important paracrine regulator of bone mass. It has recently been shown that osteocyte production of receptor activator of NF‐κB ligand (RANKL) is important in osteoclastic bone resorption, and we reported that exogenous treatment of osteocytes with...

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Bibliographic Details
Published in:	Journal of bone and mineral research 2013-12, Vol.28 (12), p.2436-2448
Main Authors:	Kogawa, Masakazu, Wijenayaka, Asiri R, Ormsby, Renee T, Thomas, Gethin P, Anderson, Paul H, Bonewald, Lynda F, Findlay, David M, Atkins, Gerald J
Format:	Article
Language:	English
Subjects:	Animals Bone and Bones - drug effects Bone and Bones - metabolism Bone Morphogenetic Proteins - metabolism Calcium - metabolism CARBONIC ANHYDRASE 2 Carbonic Anhydrases - biosynthesis Cell Line Cell Size - drug effects Enzyme Induction - drug effects Gene Expression Regulation - drug effects Gene Knockdown Techniques Genetic Markers Glycoproteins - metabolism Humans Hydrogen-Ion Concentration - drug effects Mice Minerals - metabolism OSTEOCYTE Osteocytes - drug effects Osteocytes - enzymology Osteocytes - metabolism OSTEOCYTIC OSTEOLYSIS Recombinant Proteins - pharmacology RNA, Small Interfering - metabolism SCLEROSTIN SOST
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