Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells

The tumorigenicity of human pluripotent stem cells is a major safety concern for their application in regenerative medicine. Here we identify the tight-junction protein Claudin-6 as a cell-surface-specific marker of human pluripotent stem cells that can be used to selectively remove Claudin-6-positi...

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Bibliographic Details
Published in:Nature communications 2013-06, Vol.4 (1), p.1992, Article 1992
Main Authors: Ben-David, Uri, Nudel, Neta, Benvenisty, Nissim
Format: Article
Language:English
Subjects:
631/1647/1407
631/532/2064
631/61/490
Animals
Carcinogenesis - drug effects
Carcinogenesis - metabolism
Carcinogenesis - pathology
Cell Death - drug effects
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Cell Survival - drug effects
Claudins - genetics
Claudins - immunology
Claudins - metabolism
Down-Regulation - drug effects
Down-Regulation - genetics
Embryonic Stem Cells - drug effects
Embryonic Stem Cells - metabolism
Embryonic Stem Cells - pathology
Enterotoxins - pharmacology
Fibroblasts - drug effects
Fibroblasts - metabolism
Fibroblasts - pathology
Humanities and Social Sciences
Humans
Mice
multidisciplinary
Pluripotent Stem Cells - drug effects
Pluripotent Stem Cells - metabolism
Pluripotent Stem Cells - pathology
Science
Science (multidisciplinary)
Stem cells
Teratoma - metabolism
Teratoma - pathology
Tight Junction Proteins - genetics
Tight Junction Proteins - immunology
Tight Junction Proteins - metabolism
Toxins
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