Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo

Nitrogen activation: Though P450 enzymes are masters of oxygen activation and insertion into CH bonds, their ability to use nitrogen for the same purpose has so far not been explored. Engineered variants of cytochrome P450BM3 have now been found to catalyze intramolecular CH aminations in azide su...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-08, Vol.52 (35), p.9309-9312
Main Authors: McIntosh, John A., Coelho, Pedro S., Farwell, Christopher C., Wang, Z. Jane, Lewis, Jared C., Brown, Tristan R., Arnold, Frances H.
Format: Article
Language:English
Subjects:
Amination
Biocatalysis
Cytochrome P-450 Enzyme System - chemistry
Cytochrome P-450 Enzyme System - metabolism
cytochromes
CH activation
enzyme catalysis
Molecular Structure
Protein Engineering
Stereoisomerism
Sulfonamides - chemistry
Sulfonamides - metabolism
synthetic biology
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