Increased Total Renin Levels but Not Angiotensin-Converting Enzyme Activity in Obese Patients with Polycystic Ovary Syndrome

Objective: To investigate the renin-angiotensin-aldosterone system and angiotensin-converting enzyme (ACE) activity in patients with polycystic ovarian syndrome (PCOS). Subjects and Methods: In this case-control study, 41 obese (PCOS) women and 29 healthy controls, matched for age and body mass inde...

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Bibliographic Details
Published in:Medical principles and practice 2013-01, Vol.22 (5), p.475-479
Main Authors: Alphan, Ziynet, Berberoglu, Zehra, Gorar, Suheyla, Candan, Zehra, Aktas, Aynur, Aral, Yalcin, Ademoglu, Esranur
Format: Article
Language:English
Subjects:
Adiposity - physiology
Adult
Body Mass Index
Body Weights and Measures
Female
Hormones - blood
Humans
Obesity - blood
Obesity - etiology
Obesity - metabolism
Original Paper
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - metabolism
Renin - blood
Renin - metabolism
Renin-Angiotensin System - physiology
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Summary:Objective: To investigate the renin-angiotensin-aldosterone system and angiotensin-converting enzyme (ACE) activity in patients with polycystic ovarian syndrome (PCOS). Subjects and Methods: In this case-control study, 41 obese (PCOS) women and 29 healthy controls, matched for age and body mass index, were enrolled. Anthropometric, metabolic, and hormonal patterns, including plasma aldosterone, plasma renin, and ACE activity, were measured in each subject. Results: Plasma renin levels were significantly higher in PCOS patients (19.7 ± 14.5 µg/ml) compared with controls (12.9 ± 9.0 µg/ml, p < 0.05). ACE activity and aldosterone levels did not significantly differ between both groups (p = 0.15 and p = 0.18, respectively). Analysis of PCOS patients showed a significant correlation of fasting insulin levels with levels of renin (r = 0.305, p < 0.01) and free testosterone (r = 0.384, p = 0.001). Similarly, homeostasis model assessment index was positively correlated with total renin concentrations (r = 0.366, p < 0.01) and free testosterone (r = 0.352, p < 0.01). Conclusion: Obese PCOS women had higher total renin levels, but not ACE activity and aldosterone levels, related to insulin resistance compared with controls.
ISSN:1011-7571
1423-0151
DOI:10.1159/000351572