Effects of exercise and poor indoor air quality on learning, memory and blood IGF-1 in adolescent mice

• Published in: Biotechnic & histochemistry 2014-02, Vol.89 (2), p.126-135
• Main Authors: Uysal, N, Kiray, M, Sisman, AR, Baykara, B, Aksu, I, Dayi, A, Gencoglu, C, Evren, M, Buyuk, E, Cetin, F, Acikgoz, O
• Format: Article
• Language: English
• Subjects: adolescent; Air Pollution, Indoor; air quality; Animals; Blood Chemical Analysis; carbon dioxide; exercise; hippocampus; Hippocampus - metabolism; IGF-1; Insulin-Like Growth Factor I - analysis; learning; Learning - physiology; memory; Memory - physiology; Mice; Mice, Inbred BALB C; Physical Conditioning, Animal; prefrontal cortex; Prefrontal Cortex - metabolism
• ISSN: 1052-0295; 1473-7760
• DOI: 10.3109/10520295.2013.825318

Abstract It is known that regular aerobic exercise enhances cognitive functions and increases blood insulin-like growth factor 1 (IGF-1) levels. People living in urban areas spend most of their time indoors and indoor air quality can affect health. We investigated the effects of aerobic exercise in poor and good air quality environments on hippocampus and prefrontal cortex (PFC) neurons, anxiety, and spatial learning and memory in adolescent mice. Poor air quality impaired spatial learning and memory; exercise did not affect learning or memory impairment. Exercise in a good air quality environment improved spatial learning and memory. Poor air quality increased apoptosis in the hippocampus and PFC. Both exercised and sedentary groups living in a poor air quality environment had lower serum IGF-1 levels than those living in a good air quality environment. Living in a poor air quality environment has negative effects on the hippocampus, PFC and blood IGF-1 levels in adolescent mice, but exercise did not alter the negative effects of poor air quality.