Preeclampsia is an independent risk factor for spontaneous intestinal perforation in very preterm infants

Abstract Background: Spontaneous intestinal perforation (SIP) is an important surgical emergency in preterm infants. Aims: To evaluate the effect of maternal preeclampsia on development of SIP in premature infants. Study design: Retrospective observational study in a large tertiary neonatal intensiv...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2014-08, Vol.27 (12), p.1248-1251
Main Authors: Y lmaz, Yavuz, Kutman, H. Gözde Kanmaz, Ulu, Hülya Özkan, Canpolat, F. Emre, Ura, Nurdan, O uz, S. Suna, Dilmen, Ugur
Format: Article
Language:English
Subjects:
Adult
Antenatal steroids
Case-Control Studies
Female
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - epidemiology
Infant, Premature, Diseases - etiology
Infant, Very Low Birth Weight
Intestinal Perforation - epidemiology
Intestinal Perforation - etiology
intrauterin growth retardation
Male
Pre-Eclampsia - epidemiology
preeclampsia
Pregnancy
prematurity
Retrospective Studies
Risk Factors
Rupture, Spontaneous - epidemiology
Rupture, Spontaneous - etiology
spontaneous intestinal perforation
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Summary:Abstract Background: Spontaneous intestinal perforation (SIP) is an important surgical emergency in preterm infants. Aims: To evaluate the effect of maternal preeclampsia on development of SIP in premature infants. Study design: Retrospective observational study in a large tertiary neonatal intensive care unit. Subjects: The preterm infants of 32 weeks of gestational age and birthweight 1500 g who were hospitalized were enrolled. Outcome measures: The primary outcome was to determine the association between preeclampsia and SIP. Results: A total of 22 infants had SIP diagnosis. The incidence of SIP in infants born to preeclamptic mothers (6.2%) was significantly higher compared with those born to normotensive mothers (0.2%). In multinominal logistic regression model, preeclampsia was found to be an independent risk factor of SIP with an odds ratio of 13.5 (95% confidence interval 2.82-65.1). Conclusions: Maternal preeclampsia seemed to be an independent risk factor for development of SIP in premature infants.
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2013.851189