Hypocalcaemia as a prognostic factor of early mortality in moderate and severe traumatic brain injury

Objectives: Our main objective was to evaluate whether serum hypocalcaemia on the third day [defined as < 2·1 mmol/l (8·5 mg/dl)] is a prognostic factor for early mortality after moderate and severe traumatic brain injury (TBI). Methods: We developed an ambispective comparative case control study...

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Bibliographic Details
Published in:Neurological research (New York) 2014-02, Vol.36 (2), p.102-106
Main Authors: Vinas-Rios, Juan Manuel, Sanchez-Aguilar, Martin, Sanchez-Rodriguez, Jose Juan, Gonzalez-Aguirre, Daniel, Heinen, Christian, Meyer, Frerk, Kretschmer, Thomas
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Brain Injuries - diagnosis
Brain Injuries - mortality
Calcium - blood
Case-Control Studies
Child
Child, Preschool
Female
Humans
Hypocalcaemia
Hypocalcemia - diagnosis
Infant
Male
Middle Aged
Predictive mortality factor
Prognosis
Prospective Studies
Retrospective Studies
Severity of Illness Index
Traumatic brain injury
Young Adult
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Summary:Objectives: Our main objective was to evaluate whether serum hypocalcaemia on the third day [defined as < 2·1 mmol/l (8·5 mg/dl)] is a prognostic factor for early mortality after moderate and severe traumatic brain injury (TBI). Methods: We developed an ambispective comparative case control study. We evaluated clinical profiles from included patients from January 2005 to July 2009 and we prospectively recruited additional patients from August 2009 to July 2011. Patients were between 1 and 89 years old and had a Glasgow Coma Scale of 3-12 points following TBI. Results: We calculated an Odds Ratio of 5·2 (Confidence Intervals 95%: 4·48 to 6·032) for hypocalcaemia on day three, which was associated with death. Retrospectively (January 2005 to July 2009) we compiled data from 81 patients. Prospectively (August 2009 to July 2011) we recruited 41 patients. The adjusted variables in the logistic regression final model were: serum calcium on day three (Odds Ratio 3·5, Confidence Intervals 95%: 1·12 to 13·61, P < 0·028) and anisocoria (Odds Ratio 8·24, Confidence Intervals 95%: 1·3 to 67·35, P < 0·019) obtaining an adjusted R2 of 0·22 (P < 0·005). Discussion: The serum levels of calcium on day three could be useful for the prediction of mortality in patients with moderate and severe TBI.
ISSN:0161-6412
1743-1328
DOI:10.1179/1743132813Y.0000000272