Prerequisite OCT4 Maintenance Potentiates the Neural Induction of Differentiating Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

Establishing an efficient differentiation procedure is prerequisite for the cell transplantation of pluripotent stem cells. Activating fibroblast growth factor (FGF) signals and inhibiting the activin/nodal pathway are both conserved principles to direct the neural induction (NI) of developing embry...

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Bibliographic Details
Published in:Cell transplantation 2015-05, Vol.24 (5), p.829-844
Main Authors: Chen, Sheng-Mei, Lee, Maw-Sheng, Chang, Chia-Yu, Lin, Shinn-Zong, Cheng, En-Hui, Liu, Yung-Hsien, Pan, Hong-Chuan, Lee, Hsiu-Chin, Su, Hong-Lin
Format: Article
Language:English
Subjects:
Benzamides - pharmacology
Cell Differentiation
Cell Survival - drug effects
Cell Survival - genetics
Dioxoles - pharmacology
Embryonic Stem Cells - cytology
Embryonic Stem Cells - metabolism
Fibroblast Growth Factor 2 - pharmacology
Humans
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - metabolism
Neurons - cytology
Neurons - metabolism
Octamer Transcription Factor-3 - genetics
Octamer Transcription Factor-3 - metabolism
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