Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes

Adaptive immunity is initiated in T-cell zones of secondary lymphoid organs. These zones are organized in a rigid 3D network of fibroblastic reticular cells (FRCs) that are a rich cytokine source. In response to lymph-borne antigens, draining lymph nodes (LNs) expand several folds in size, but the f...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS 2014-01, Vol.111 (1), p.E109-E118
Main Authors:	Yang, Chen-Ying, Vogt, Tobias K., Favre, Stéphanie, Scarpellino, Leonardo, Huang, Hsin-Ying, Tacchini-Cottier, Fabienne, Luther, Sanjiv A.
Format:	Article
Language:	English
Subjects:	Adaptive Immunity Animals Antigens Biological Sciences Cell growth Cell Movement Cell Proliferation Cytokines dendritic cells Dendritic Cells - cytology fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Homeostasis hyperplasia Immune response Immunity (Disease) Immunology and Inflammation Inflammation Lymph nodes Lymph Nodes - immunology Lymph Nodes - metabolism Lymphatic system Lymphocyte Activation Lymphocytes Lymphocytes - cytology Lymphotoxin-alpha - metabolism Mice Mice, Inbred C57BL Microscopy, Fluorescence - methods Myeloid Differentiation Factor 88 - metabolism PNAS Plus Stromal Cells - cytology T-lymphocytes T-Lymphocytes - cytology Trapping
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