Transfer of omega‐3 fatty acids across the blood–brain barrier after dietary supplementation with a docosahexaenoic acid‐rich omega‐3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study

Objective Little is known about the transfer of essential fatty acids (FAs) across the human blood–brain barrier (BBB) in adulthood. In this study, we investigated whether oral supplementation with omega‐3 (n‐3) FAs would change the FA profile of the cerebrospinal fluid (CSF). Methods A total of 33...

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Bibliographic Details
Published in:Journal of internal medicine 2014, Vol.275 (4), p.428-436
Main Authors: Freund Levi, Y., Vedin, I., Cederholm, T., Basun, H., Faxén Irving, G., Eriksdotter, M., Hjorth, E., Schultzberg, M., Vessby, B., Wahlund, L.‐O., Salem, N., Palmblad, J.
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Alzheimer Disease - blood
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - drug therapy
Alzheimer's disease
Biomarkers - blood
Biomarkers - cerebrospinal fluid
Blood-Brain Barrier
cerebrospinal fluid
Dietary Supplements
Disease Progression
docosahexaenoic acid
Docosahexaenoic Acids - administration & dosage
Docosahexaenoic Acids - pharmacokinetics
Docosahexaenoic Acids - therapeutic use
Double-Blind Method
eicosapentaenoic acid
Eicosapentaenoic Acid - administration & dosage
Eicosapentaenoic Acid - blood
Eicosapentaenoic Acid - cerebrospinal fluid
Eicosapentaenoic Acid - metabolism
Fatty Acids, Omega-3 - administration & dosage
Fatty Acids, Omega-3 - blood
Fatty Acids, Omega-3 - cerebrospinal fluid
Fatty Acids, Omega-3 - metabolism
Follow-Up Studies
Humans
omega-3 fatty acids
Phosphorylation
tau Proteins - blood
tau Proteins - cerebrospinal fluid
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