PECAM-1: regulator of endothelial junctional integrity

PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprising six extracellular immunoglobulin (Ig)-like homology domains, a short transmembrane domain and a 118 amino acid cytoplasmic domain that becomes serine and tyrosine phosphorylated upon cellular activation. PECAM-1 ex...

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Bibliographic Details
Published in:Cell and tissue research 2014-03, Vol.355 (3), p.607-619
Main Authors: Privratsky, Jamie R, Newman, Peter J
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Blood platelets
cell adhesion
Cell adhesion & migration
Cell Adhesion - physiology
cytology
endothelial cells
Endothelial Cells - cytology
Endothelial Cells - metabolism
Endothelium
Human Genetics
Humans
Immunoglobulins
intercellular junctions
Intercellular Junctions - metabolism
Intercellular Junctions - physiology
leukocytes
metabolism
Molecular Medicine
Permeability
Phosphorylation
physical properties
physiology
Platelet Endothelial Cell Adhesion Molecule-1
Platelet Endothelial Cell Adhesion Molecule-1 - metabolism
Proteomics
Review
sequence homology
serine
tyrosine
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