A pragmatic randomized trial of a polypill-based strategy to improve use of indicated preventive treatments in people at high cardiovascular disease risk

Background Most individuals at high cardiovascular disease (CVD) risk worldwide do not receive any or optimal preventive drugs. We aimed to determine whether fixed dose combinations of generic drugs (‘polypills’) would promote use of such medications. Methods We conducted a randomized, open-label tr...

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Bibliographic Details
Published in:European journal of preventive cardiology 2015-07, Vol.22 (7), p.920-930
Main Authors: Patel, Anushka, Cass, Alan, Peiris, David, Usherwood, Tim, Brown, Alex, Jan, Stephen, Neal, Bruce, Hillis, Graham S, Rafter, Natasha, Tonkin, Andrew, Webster, Ruth, Billot, Laurent, Bompoint, Severine, Burch, Carol, Burke, Hugh, Hayman, Noel, Molanus, Barbara, Reid, Christopher M, Shiel, Louise, Togni, Samantha, Rodgers, Anthony
Format: Article
Language:English
Subjects:
Administration, Oral
Adrenergic beta-1 Receptor Antagonists - administration & dosage
Aged
Angiotensin-Converting Enzyme Inhibitors - administration & dosage
Antihypertensive Agents - administration & dosage
Aspirin - administration & dosage
Atenolol - administration & dosage
Australia
Biomarkers - blood
Blood Pressure - drug effects
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - etiology
Cardiovascular Diseases - physiopathology
Cardiovascular Diseases - prevention & control
Cholesterol - blood
Drug Combinations
Drugs, Generic - administration & dosage
Female
General Practice
Humans
Hydrochlorothiazide - administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hyperlipidemias - blood
Hyperlipidemias - complications
Hyperlipidemias - diagnosis
Hyperlipidemias - drug therapy
Hypertension - complications
Hypertension - diagnosis
Hypertension - drug therapy
Hypertension - physiopathology
Lisinopril - administration & dosage
Male
Middle Aged
Platelet Aggregation Inhibitors - administration & dosage
Polypharmacy
Primary Prevention - methods
Prospective Studies
Risk Factors
Simvastatin - administration & dosage
Sodium Chloride Symporter Inhibitors - administration & dosage
Tablets
Time Factors
Treatment Outcome
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