Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT Phenotype for Drug Testing

Human induced pluripotent stem cells (iPSCs) play an important role in disease modeling and drug testing. However, the current methods are time-consuming and lack an isogenic control. This study sought to establish an efficient technology to generate human PSC-based disease models with isogenic cont...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2014-08, Vol.64 (5), p.451-459
Main Authors: Wang, Yongming, Liang, Ping, Lan, Feng, Wu, Haodi, Lisowski, Leszek, Gu, Mingxia, Hu, Shijun, Kay, Mark A., Urnov, Fyodor D., Shinnawi, Rami, Gold, Joseph D., Gepstein, Lior, Wu, Joseph C.
Format: Article
Language:English
Subjects:
Anti-Arrhythmia Agents - therapeutic use
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiomyocytes
Cardiomyopathy
Cardiovascular
Cell Differentiation
Cell Transdifferentiation
Cells, Cultured
Cloning
Disease
disease models
drug testing
Editing
Epigenetics
Genes
Genome
genome editing
Genomes
Genotype & phenotype
Heart
Humans
Induced Pluripotent Stem Cells - metabolism
Induced Pluripotent Stem Cells - pathology
Long QT syndrome
Long QT Syndrome - drug therapy
Long QT Syndrome - genetics
Long QT Syndrome - pathology
Medical sciences
Mutation
Patch-Clamp Techniques
Polymerase chain reaction
Stem cells
stem cells
Studies
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