Fungal natural products in research and development

• Published in: Natural product reports 2014-10, Vol.31 (1), p.1425-1448
• Main Authors: Schueffler, Anja, Anke, Timm
• Format: Article
• Language: English
• Subjects: Biological Products - chemistry; Biological Products - isolation & purification; Biological Products - metabolism; Fungi - chemistry; Fungi - metabolism; Molecular Structure
• ISSN: 0265-0568; 1460-4752
• DOI: 10.1039/c4np00060a

Covering: 2009 to 2013 To date approximately 100 000 fungal species are known although far more than one million are expected. The variety of species and the diversity of their habitats, some of them less exploited, allow the conclusion that fungi continue to be a rich source of new metabolites. Besides the conventional fungal isolates, an increasing interest in endophytic and in marine-derived fungi has been noticed. In addition new screening strategies based on innovative chemical, biological, and genetic approaches have led to novel fungal metabolites in recent years. The present review focuses on new fungal natural products published from 2009 to 2013 highlighting the originality of the structures and their biological potential. Furthermore synthetic products based on fungal metabolites as well as new developments in the uses or the biological activity of known compounds or new derivatives are discussed. This review focuses on new fungal natural products published from 2009 to 2013 highlighting the originality of the structures and their biological potential. Additionally progress in the use or the biological activity of known compounds or new derivatives is emphasized.