Acetate Dependence of Tumors

Acetyl-CoA represents a central node of carbon metabolism that plays a key role in bioenergetics, cell proliferation, and the regulation of gene expression. Highly glycolytic or hypoxic tumors must produce sufficient quantities of this metabolite to support cell growth and survival under nutrient-li...

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Bibliographic Details
Published in:Cell 2014-12, Vol.159 (7), p.1591-1602
Main Authors: Comerford, Sarah A., Huang, Zhiguang, Du, Xinlin, Wang, Yun, Cai, Ling, Witkiewicz, Agnes K., Walters, Holly, Tantawy, Mohammed N., Fu, Allie, Manning, H. Charles, Horton, Jay D., Hammer, Robert E., McKnight, Steven L., Tu, Benjamin P.
Format: Article
Language:English
Subjects:
acetate-CoA ligase
Acetate-CoA Ligase - analysis
Acetate-CoA Ligase - genetics
Acetate-CoA Ligase - metabolism
acetates
Acetates - metabolism
acetyl coenzyme A
Acetyl Coenzyme A - metabolism
adults
Animals
carbon
cell growth
cell proliferation
energy metabolism
gene expression regulation
glycolysis
hepatoma
histones
Humans
Immunohistochemistry
lipids
Liver Neoplasms - metabolism
metabolites
Mice
Neoplasms - chemistry
Neoplasms - metabolism
Neoplasms - pathology
Positron-Emission Tomography
Triple Negative Breast Neoplasms - chemistry
Triple Negative Breast Neoplasms - pathology
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