Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells

The naturally occurring triterpenoid betulinic acid (BA) shows pronounced polypharmacology ranging from anti-inflammatory to anti-lipogenic activities. Recent evidence suggests that rather diverse cellular signaling events may be attributed to the same common upstream switch in cellular metabolism....

Full description

Saved in:

Bibliographic Details
Published in:	PloS one 2014-12, Vol.9 (12), p.e115683
Main Authors:	Heiss, Elke H., Kramer, Matthias P., Atanasov, Atanas G., Beres, Hortenzia, Schachner, Daniel, Dirsch, Verena M.
Format:	Article
Language:	English
Subjects:	Acids Activation AMP AMP-activated protein kinase AMP-Activated Protein Kinases - physiology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Apoptosis Betulinic Acid Bioenergetics Biology and Life Sciences Blotting, Western Cancer Cell death Cell Proliferation - drug effects Cells, Cultured Cytotoxicity Embryo fibroblasts Embryo, Mammalian - cytology Embryo, Mammalian - drug effects Embryo, Mammalian - metabolism Embryos Energy Metabolism Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Glucose Glucose - metabolism Glycolysis Glycolysis - drug effects Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Immunoglobulins Inflammation Kinases Liver LKB1 protein Metabolism Mice Mice, Knockout Mitochondria Mitochondria - drug effects Mitochondria - metabolism Oxidation Oxidation-Reduction Pentacyclic Triterpenes Permeability Phosphorylation - drug effects Protein Serine-Threonine Kinases - physiology Proteins Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Rodents Signal transduction Signaling Triterpenes - pharmacology
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!