Insulin resistance and impaired adipogenesis

•Subcutaneous adipose tissue has a finite expansion capacity.•Adipose cell expansion (hypertrophic obesity) is associated with abdominal obesity and insulin resistance.•The ability to increase subcutaneous adipogenesis is protective.•BMP4 regulates both white and beige/brown subcutaneous adipogenesi...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2015-04, Vol.26 (4), p.193-200
Main Authors: Gustafson, Birgit, Hedjazifar, Shahram, Gogg, Silvia, Hammarstedt, Ann, Smith, Ulf
Format: Article
Language:English
Subjects:
Adipogenesis
Adipose Tissue, Brown - immunology
Adipose Tissue, Brown - metabolism
Adipose Tissue, Brown - pathology
Adiposity
Animals
BMP4
Cell and Molecular Biology
Cell- och molekylärbiologi
Down-Regulation
Endocrinology & Metabolism
Glucose Transporter Type 4 - genetics
Glucose Transporter Type 4 - metabolism
Gremlin1
Humans
Hypertrophy
Insulin Resistance
Lipid Metabolism
Metabolic Syndrome - genetics
Metabolic Syndrome - immunology
Metabolic Syndrome - metabolism
Metabolic Syndrome - pathology
Models, Biological
obesity
Organ Specificity
Subcutaneous Fat, Abdominal - immunology
Subcutaneous Fat, Abdominal - metabolism
Subcutaneous Fat, Abdominal - pathology
type 2 diabetes
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