Residential radon and lung cancer characteristics in never smokers

Purpose: The aim of this study is to assess if there is a relationship between residential radon and lung cancer histological types and patients' age at diagnosis. Materials and methods: We conducted a multicenter hospital-based case-control study with eight participating hospitals. We included...

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Bibliographic Details
Published in:International journal of radiation biology 2015-08, Vol.91 (8), p.605-610
Main Authors: Torres-Durán, María, Ruano-Ravina, Alberto, Parente-Lamelas, Isaura, Leiro-Fernández, Virginia, Abal-Arca, José, Montero-Martínez, Carmen, Pena-Álvarez, Carolina, Castro-Añón, Olalla, Golpe-Gómez, Antonio, Martínez, Cristina, Guzmán-Taveras, Rosirys, Mejuto-Martí, María José, Provencio, Mariano, Fernández-Villar, Alberto, Barros-Dios, Juan Miguel
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
Air Pollution, Indoor - statistics & numerical data
Air Pollution, Radioactive - statistics & numerical data
Case-Control Studies
Female
histologic type
Housing - statistics & numerical data
Humans
Lung neoplasms
Lung Neoplasms - epidemiology
Lung Neoplasms - pathology
Male
Middle Aged
multicenter study
Neoplasms, Radiation-Induced - epidemiology
Neoplasms, Radiation-Induced - pathology
Radiation Exposure - statistics & numerical data
radon
Radon - analysis
Risk Factors
Sex Distribution
Smoking - epidemiology
Space life sciences
Spain - epidemiology
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Summary:Purpose: The aim of this study is to assess if there is a relationship between residential radon and lung cancer histological types and patients' age at diagnosis. Materials and methods: We conducted a multicenter hospital-based case-control study with eight participating hospitals. We included 216 never-smoking cases with primary lung cancer and 329 never-smoking controls. Controls were frequency matched with cases on age and sex distribution. Of them, 198 cases (91.7%) and 275 controls (83.5%) had residential radon measurements. Results: Lung cancer risk reached statistical significance only for adenocarcinoma (Odds ratio [OR] 2.19; 95% Confidence interval [CI] 1.44-3.33), for other histologies the results were marginally significant. Residential radon level was higher for patients diagnosed before 50 and 60 years old than for older lung cancer cases. Conclusions: Residential radon in never smokers seems to be a risk factor for all lung cancer histologies. Individuals diagnosed at a younger age have a higher residential radon concentration, suggesting an accumulative effect on lung cancer appearance.
ISSN:0955-3002
1362-3095
DOI:10.3109/09553002.2015.1047985