Donor-Derived Cell-Free DNA Is a Novel Universal Biomarker for Allograft Rejection in Solid Organ Transplantation

In solid organ transplantation, sensitive real-time biomarkers to assess the graft health are desirable to enable early intervention, for example, to avoid full-blown rejections. During rejection, high amounts of graft-derived cell-free DNA (GcfDNA) are shed into the blood stream. The quantification...

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Bibliographic Details
Published in:Transplantation proceedings 2015-10, Vol.47 (8), p.2400-2403
Main Authors: Beck, J., Oellerich, M., Schulz, U., Schauerte, V., Reinhard, L., Fuchs, U., Knabbe, C., Zittermann, A., Olbricht, C., Gummert, J.F., Shipkova, M., Birschmann, I., Wieland, E., Schütz, E.
Format: Article
Language:English
Subjects:
Allografts
Biomarkers - blood
Cross-Sectional Studies
DNA - blood
Graft Rejection - blood
Graft Rejection - diagnosis
Heart Transplantation
Humans
Kidney
Kidney Transplantation
Polymerase Chain Reaction
Surgery
Tissue Donors
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