Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver

Endocrine functions of the heart have been well established. We investigated the hypothesis that cardiac secretion of a unique phospholipase A2 recently identified by our laboratory (cardiac secreted phospholipase A2 [sPLA2]) establishes a heart-liver endocrine axis that is negatively regulated by m...

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Bibliographic Details
Published in:	Journal of the American Heart Association 2015-11, Vol.4 (11)
Main Authors:	Hernandez-Anzaldo, Samuel, Berry, Evan, Brglez, Vesna, Leung, Dickson, Yun, Tae Jin, Lee, Jun Seong, Filep, Janos G, Kassiri, Zamaneh, Cheong, Cheolho, Lambeau, Gérard, Lehner, Richard, Fernandez-Patron, Carlos
Format:	Article
Language:	English
Subjects:	Acetates - pharmacology Animals Antibodies - pharmacology Cells, Cultured Chemokine CCL7 - antagonists & inhibitors Chemokine CCL7 - metabolism Cholesterol, Dietary - metabolism Enzyme Inhibitors - pharmacology Gene Expression Regulation Genetic Predisposition to Disease Hepatitis - enzymology Hepatitis - genetics Hepatitis - immunology Hepatitis - prevention & control Indoles - pharmacology Keto Acids Lipid Metabolism - drug effects Lipid Metabolism - genetics Liver - drug effects Liver - enzymology Liver - immunology Matrix Metalloproteinase 2 - deficiency Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Mice, Inbred C57BL Mice, Knockout Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Original Research Phenotype Phospholipases A2, Secretory - antagonists & inhibitors Phospholipases A2, Secretory - metabolism Signal Transduction Time Factors Transcription, Genetic Triglycerides - metabolism
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