The Localization and Action of Topoisomerase IV in Escherichia coli Chromosome Segregation Is Coordinated by the SMC Complex, MukBEF

The type II topoisomerase TopoIV, which has an essential role in Escherichia coli chromosome decatenation, interacts with MukBEF, an SMC (structural maintenance of chromosomes) complex that acts in chromosome segregation. We have characterized the intracellular dynamics of individual TopoIV molecule...

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Bibliographic Details
Published in:Cell reports (Cambridge) 2015-12, Vol.13 (11), p.2587-2596
Main Authors: Zawadzki, Pawel, Stracy, Mathew, Ginda, Katarzyna, Zawadzka, Katarzyna, Lesterlin, Christian, Kapanidis, Achillefs N., Sherratt, David J.
Format: Article
Language:English
Subjects:
Biocatalysis
Catenanes - metabolism
Chromosomal Proteins, Non-Histone - genetics
Chromosomal Proteins, Non-Histone - metabolism
Chromosome Segregation
Chromosomes, Bacterial - metabolism
DNA Topoisomerase IV - metabolism
Escherichia coli - enzymology
Escherichia coli - genetics
Escherichia coli - metabolism
Escherichia coli Proteins - genetics
Escherichia coli Proteins - metabolism
Microscopy, Fluorescence
Multigene Family
Replication Origin
Repressor Proteins - genetics
Repressor Proteins - metabolism
Time-Lapse Imaging
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