CLINICAL STUDIES AND SPUTUM LEVELS OF CEFTRIAXONE ONCE DAILY ADMINISTRATION IN THE RESPIRATORY TRACT INFECTION

Ceftriaxone (CTRX), a new cephalosporin, was investigated by once daily administration for its clinical efficacy and safety on respiratory tract infections. The results obtained are summarized as follows: 1. Clinical responses to CTRX of a total of 39 cases with respiratory tract infections were exc...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1989/04/25, Vol.42(4), pp.921-929
Main Authors: KUWABARA, MASAO, SASAKI, HIDEO, FUKUHARA, HIROFUMI, ARITA, HIROYUKI, INAMIZU, TSUTOMU, SADAMOTO, KENICHIRO, KIMURA, TOSHIKI, YAMANE, KIMINORI, SHIGEMOTO, MIHO, KAWAMOTO, MASAHIDE, HASEGAWA, KENJI, KAMITSUNA, AKIMITSU, YAMAKIDO, MICHIO, NISHIMOTO, YUKIO
Format: Article
Language:Japanese
Subjects:
Adult
Aged
Aged, 80 and over
Ceftriaxone - administration & dosage
Ceftriaxone - adverse effects
Ceftriaxone - pharmacokinetics
Drug Administration Schedule
Drug Evaluation
Female
Humans
Infusions, Intravenous
Injections, Intravenous
Male
Middle Aged
Multicenter Studies as Topic
Respiratory Tract Infections - drug therapy
Respiratory Tract Infections - metabolism
Sputum - metabolism
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Summary:Ceftriaxone (CTRX), a new cephalosporin, was investigated by once daily administration for its clinical efficacy and safety on respiratory tract infections. The results obtained are summarized as follows: 1. Clinical responses to CTRX of a total of 39 cases with respiratory tract infections were excellent in 12 cases, good in 23, fair in 3, poor in 1 with an efficacy rate of 89.7%. Against acute bronchitis, lung abscess, bronchiectasis, chronic bronchitis and obstructive pneumonia, efficacy rates were 100%. 2. Serum levels and urinary excretion rates of CTRX were investigated in 2 cases after intravenous drip infusion of the drug at doses of 1g and 2g, respectively. Although urinary excretion rate tended to decrease with the deterioration of renal functions, prolongation of serum half-life was slight in those patients with normal liver function. In 1 case, it remained at 1.9μg/ml at 12 hours and in another at 0.9μg/ml at 22 hours in sputum. According to the results, it appears that once daily administration of CTRX is effective and well tolerated in patients with acute respiratory infections.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.42.921