Treatment Results of MammoSite Catheter in Combination with Whole-breast Irradiation

To report the initial outcomes of patients treated with the MammoSite brachytherapy device (MSBT) as a boost followed by external whole-breast irradiation (WBI). From June 2011 to March 2014, 107 patients (typically with pT1-2, pN0-1, M0 disease) were treated with breast-conserving therapy and adjuv...

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Bibliographic Details
Published in:Anticancer research 2016-01, Vol.36 (1), p.355
Main Authors: Gitt, Alexander, Böse-Ribeiro, Hugo, Nieder, Carsten, Kup, Philipp Günther, Hermani, Horst, Bühler, Helmut, Ergönenç, Hasan Yavuz, Drüppel, Dorothee, Adamietz, Irenäus Anton, Fakhrian, Khashayar
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Brachytherapy - methods
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Dose Fractionation
Female
Humans
Mastectomy, Segmental - methods
Middle Aged
Treatment Outcome
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Summary:To report the initial outcomes of patients treated with the MammoSite brachytherapy device (MSBT) as a boost followed by external whole-breast irradiation (WBI). From June 2011 to March 2014, 107 patients (typically with pT1-2, pN0-1, M0 disease) were treated with breast-conserving therapy and adjuvant radiotherapy with MSBT (15 Gy in 2.5-Gy fractions) followed by WBI (median=50.4 Gy). Toxicity was classified according to the Common Terminology Criteria for Adverse Events v3.0. The median follow-up was 21 months. To date, no ipsilateral breast-tumor recurrences have been observed; 102 patients (95%) were alive at last follow-up. Two patients (2%) developed distant metastases. Five patients (5%) died during follow-up, only one as a result of breast cancer. The 2-year disease-free survival was 95±3%. The incidence of asymptomatic and symptomatic seroma in 90 days after MSBT was 28% and 10%, respectively. Infectious mastitis was observed in three patients (3%), who were treated successfully with antibiotics. Only three patients (3%) developed RT-induced dermatitis greater than grade 2 after WBI. The boost technique used in this study seems to provide excellent local control with acceptable toxicity, similar to the results observed with other forms of interstitial accelerated partial-breast irradiation as a boost. Long-term follow-up is necessary to refine the patient selection criteria and to assess efficacy and late toxicities.
ISSN:1791-7530