Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2−/−) or obese (ob/ob) mice

Reducing triacylglycerol (TAG) in the liver continues to pose a challenge in states of nonalcoholic hepatic steatosis. Monoacylglycerol O-acyltransferase (MOGAT) enzymes convert monoacylglycerol (MAG) to diacylglycerol, a precursor for TAG synthesis, and are involved in a major pathway of TAG synthe...

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Bibliographic Details
Published in:Journal of lipid research 2016-04, Vol.57 (4), p.616-630
Main Authors: Agarwal, Anil K., Tunison, Katie, Dalal, Jasbir S., Yen, Chi-Liang Eric, Jr.Farese, Robert V., Horton, Jay D., Garg, Abhimanyu
Format: Article
Language:English
Subjects:
1-acylglycerol-3-phosphate O-acyltransferase 2
Acyltransferases - deficiency
Acyltransferases - genetics
Animals
diabetes
fatty liver
Female
Gene Deletion
Insulin - blood
Insulin Resistance
lipodystrophy
Lipodystrophy - complications
Lipodystrophy - genetics
Lipodystrophy - metabolism
Liver - metabolism
Male
Mice
Mice, Obese
monoacylglycerol O-acyltransferase 1
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - enzymology
Non-alcoholic Fatty Liver Disease - genetics
Non-alcoholic Fatty Liver Disease - metabolism
ob/ob
RNA, Messenger - genetics
RNA, Messenger - metabolism
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