MLKL forms cation channels

The mixed lineage kinase domain-like （MLKL） protein is a key factor in tumor necrosis factor-induced necropto- sis. Recent studies on necroptosis execution revealed a commitment role of MLKL in membrane disruption. However, our knowledge of how MLKL functions on membrane remains very limited. Here w...

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Bibliographic Details
Published in:Cell research 2016-05, Vol.26 (5), p.517-528
Main Authors: Xia, Bingqing, Fang, Sui, Chen, Xueqin, Hu, Hong, Chen, Peiyuan, Wang, Huayi, Gao, Zhaobing
Format: Article
Language:English
Subjects:
631/45/269
631/45/607/275
631/80/82/2344
Biomedical and Life Sciences
Ca2
Cations
Cell Biology
Cell Death
HEK293 Cells
Humans
Ion Channel Gating
Ion Channels - chemistry
Ion Channels - metabolism
Life Sciences
Lipid Bilayers - metabolism
Magnesium - metabolism
N-末端
Original
original-article
Protein Kinases - chemistry
Protein Kinases - metabolism
Protein Structure, Secondary
SIS
Topology
离子通道
细胞死亡
肿瘤坏死因子
膜破裂
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