Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice

Summary DREADDs, designer receptors exclusively activated by designer drugs, are engineered G protein‐coupled receptors (GPCR) which can precisely control GPCR signaling pathways (for example, Gq, Gs, and Gi). This chemogenetic technology for control of GPCR signaling has been successfully applied i...

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Bibliographic Details
Published in:Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2016-08, Vol.54 (8), p.439-446
Main Authors: Zhu, Hu, Aryal, Dipendra K., Olsen, Reid H.J., Urban, Daniel J., Swearingen, Amanda, Forbes, Stacy, Roth, Bryan L., Hochgeschwender, Ute
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
chemogenetic
G protein-coupled receptors
Gene Targeting - methods
GsD
hM3Dq
hM4Di
Integrases - genetics
Ligands
Mice
Mice, Inbred C57BL
Protein Binding
Receptors, G-Protein-Coupled - metabolism
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