An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn Pigs

Rabies is a zoonotic infectious disease of the central nervous system (CNS). In unvaccinated or untreated subjects, rabies virus infection causes severe neurological symptoms and is invariably fatal. Despite the long-standing existence of effective vaccines, vaccine availability remains insufficient...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2016-06, Vol.10 (6), p.e0004746
Main Authors: Schnee, Margit, Vogel, Annette B., Voss, Daniel, Petsch, Benjamin, Baumhof, Patrick, Kramps, Thomas, Stitz, Lothar
Format: Article
Language:English
Subjects:
Animal bites
Animals
Animals, Newborn
Base Sequence
Biology and Life Sciences
Central nervous system
Developing countries
Domestic animals
Dose-Response Relationship, Immunologic
Drug therapy
Female
Flow cytometry
Genetic aspects
Genetic code
Glycoproteins
Glycoproteins - immunology
Health aspects
HeLa Cells
Humans
Immunoglobulins
Infections
Infectious diseases
Influenza
LDCs
Lymphocytes
Medicine and Health Sciences
Messenger RNA
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Nucleic acids
Peptide Fragments - immunology
Pregnancy
Properties
Proteins
Rabies
Rabies - mortality
Rabies - prevention & control
Rabies - veterinary
Rabies Vaccines - genetics
Rabies Vaccines - immunology
RNA polymerase
RNA, Messenger - chemistry
RNA, Messenger - immunology
Swine
Swine Diseases - prevention & control
T-Lymphocytes
Tropical diseases
Vaccines
Vaccines, Synthetic - immunology
Viral infections
Viral Proteins - immunology
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