Geometry matters: inverse cytotoxic relationship for cis/trans-Ru( ii ) polypyridyl complexes from cis/trans-[PtCl 2 (NH 3 ) 2 ]

Two thermally activated ruthenium( ii ) polypyridyl complexes, cis -Ru(bpy) 2 Cl 2 and trans -Ru(qpy)Cl 2 were investigated to determine the impact of the geometric arrangement of the exchangable ligands on the potential of the compounds to act as chemotherapeutics. In contrast to the geometry requi...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-08, Vol.52 (66), p.10121-10124
Main Authors: Wachter, Erin, Zamora, Ana, Heidary, David K., Ruiz, José, Glazer, Edith C.
Format: Article
Language:English
Subjects:
chemical reactions
cisplatin
cytotoxicity
drug therapy
geometry
Inverse
Ligands
ruthenium
structure-activity relationships
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