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Serum substance P concentrations to predict oocyte maturation index and clinical pregnancy
Aim: The aim of this study was to assess the predictive value of serum substance P (SP) concentrations on oocyte maturation and clinical pregnancy. Methods: Ninety-three women with unexplained infertility underwent intracytoplasmic sperm injection (ICSI) cycles. Antagonist protocol was started for e...
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| Published in: | Gynecological endocrinology 2017-03, Vol.33 (3), p.203-207 |
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| container_title | Gynecological endocrinology |
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| creator | Sahin, Yavuz Özkaya, Enis Kayatas Eser, Semra Kutlu, Tayfun Sanverdi, Ilhan Tunali, Gulden Karateke, Ates |
| description | Aim: The aim of this study was to assess the predictive value of serum substance P (SP) concentrations on oocyte maturation and clinical pregnancy.
Methods: Ninety-three women with unexplained infertility underwent intracytoplasmic sperm injection (ICSI) cycles. Antagonist protocol was started for each participant and at the day of oocyte pick up, serum samples were obtained from each participant to assess SP concentrations, and these concentrations were utilized to predict mature/total oocyte ratio and clinical pregnancy.
Results: SP concentration was a significant predictor for mature/total oocyte ratio > 0.75 and clinical pregnancy. In correlation analyses, maturation index was significantly correlated with FSH (r= −0.226, p = 0.03), estradiol (r = 0.239, p = 0.021), peak estradiol (r = 0.414, p |
| doi_str_mv | 10.1080/09513590.2016.1254611 |
| format | article |
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Methods: Ninety-three women with unexplained infertility underwent intracytoplasmic sperm injection (ICSI) cycles. Antagonist protocol was started for each participant and at the day of oocyte pick up, serum samples were obtained from each participant to assess SP concentrations, and these concentrations were utilized to predict mature/total oocyte ratio and clinical pregnancy.
Results: SP concentration was a significant predictor for mature/total oocyte ratio > 0.75 and clinical pregnancy. In correlation analyses, maturation index was significantly correlated with FSH (r= −0.226, p = 0.03), estradiol (r = 0.239, p = 0.021), peak estradiol (r = 0.414, p < 0.001), and substance P (r = 0.796, p < 0.001). In multivariate analyses, number of immature (beta coefficient = −0.379, p < 0.001), mature oocyte (beta coefficient = 0.473, p < 0.001), SP concentration (beta coefficient = 0.723, p < 0.001) and maturation index (beta coefficient = −0.387, p = 0.003) were significantly associated with clinical pregnancy.
Conclusion: SP concentrations at the day of oocyte pick up may be used to predict clinical pregnancy and may be an indirect indicator for cycle outcome in assisted reproductive technology (ART).</description><identifier>ISSN: 0951-3590</identifier><identifier>EISSN: 1473-0766</identifier><identifier>DOI: 10.1080/09513590.2016.1254611</identifier><identifier>PMID: 27908224</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adult ; Assisted reproduction ; Biomarkers - blood ; Chorionic Gonadotropin - pharmacology ; Cross-Sectional Studies ; Female ; Hospitals, Teaching ; Humans ; implantation ; In Vitro Oocyte Maturation Techniques ; Infertility, Female - blood ; Infertility, Female - therapy ; Luteinizing Hormone - pharmacology ; maturation index ; Oocyte Retrieval ; Oogenesis - drug effects ; Ovulation Induction ; Predictive Value of Tests ; Pregnancy ; Pregnancy Rate ; Pregnancy Tests ; ROC Curve ; Sperm Injections, Intracytoplasmic ; substance P ; Substance P - blood ; Turkey</subject><ispartof>Gynecological endocrinology, 2017-03, Vol.33 (3), p.203-207</ispartof><rights>2016 Informa UK Limited, trading as Taylor & Francis Group. 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c314t-a160a4cb564a62101a421cf7bf9446b634995c4671a25e93b38ece7845508c713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27908224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahin, Yavuz</creatorcontrib><creatorcontrib>Özkaya, Enis</creatorcontrib><creatorcontrib>Kayatas Eser, Semra</creatorcontrib><creatorcontrib>Kutlu, Tayfun</creatorcontrib><creatorcontrib>Sanverdi, Ilhan</creatorcontrib><creatorcontrib>Tunali, Gulden</creatorcontrib><creatorcontrib>Karateke, Ates</creatorcontrib><title>Serum substance P concentrations to predict oocyte maturation index and clinical pregnancy</title><title>Gynecological endocrinology</title><addtitle>Gynecol Endocrinol</addtitle><description>Aim: The aim of this study was to assess the predictive value of serum substance P (SP) concentrations on oocyte maturation and clinical pregnancy.
Methods: Ninety-three women with unexplained infertility underwent intracytoplasmic sperm injection (ICSI) cycles. Antagonist protocol was started for each participant and at the day of oocyte pick up, serum samples were obtained from each participant to assess SP concentrations, and these concentrations were utilized to predict mature/total oocyte ratio and clinical pregnancy.
Results: SP concentration was a significant predictor for mature/total oocyte ratio > 0.75 and clinical pregnancy. In correlation analyses, maturation index was significantly correlated with FSH (r= −0.226, p = 0.03), estradiol (r = 0.239, p = 0.021), peak estradiol (r = 0.414, p < 0.001), and substance P (r = 0.796, p < 0.001). In multivariate analyses, number of immature (beta coefficient = −0.379, p < 0.001), mature oocyte (beta coefficient = 0.473, p < 0.001), SP concentration (beta coefficient = 0.723, p < 0.001) and maturation index (beta coefficient = −0.387, p = 0.003) were significantly associated with clinical pregnancy.
Conclusion: SP concentrations at the day of oocyte pick up may be used to predict clinical pregnancy and may be an indirect indicator for cycle outcome in assisted reproductive technology (ART).</description><subject>Adult</subject><subject>Assisted reproduction</subject><subject>Biomarkers - blood</subject><subject>Chorionic Gonadotropin - pharmacology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Hospitals, Teaching</subject><subject>Humans</subject><subject>implantation</subject><subject>In Vitro Oocyte Maturation Techniques</subject><subject>Infertility, Female - blood</subject><subject>Infertility, Female - therapy</subject><subject>Luteinizing Hormone - pharmacology</subject><subject>maturation index</subject><subject>Oocyte Retrieval</subject><subject>Oogenesis - drug effects</subject><subject>Ovulation Induction</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Pregnancy Tests</subject><subject>ROC Curve</subject><subject>Sperm Injections, Intracytoplasmic</subject><subject>substance P</subject><subject>Substance P - blood</subject><subject>Turkey</subject><issn>0951-3590</issn><issn>1473-0766</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kEtP3DAUha2Kqgy0PwHkJZsMvn4mOxAqDwkJpJYNG8txHGSU2IPtiM6_b6IZWLI6i_udc6UPoRMgayA1OSeNACYasqYE5Bqo4BLgG1oBV6wiSsoDtFqYaoEO0VHOr4QA44r-QIdUNaSmlK_Q8x-XphHnqc3FBOvwI7ZxzlCSKT6GjEvEm-Q6bwuO0W6Lw6Mp0-6KfejcP2xCh-3gg7dmWOCXME9tf6LvvRmy-7XPY_R0_fvv1W11_3Bzd3V5X1kGvFQGJDHctkJyIykQMJyC7VXbN5zLVjLeNMJyqcBQ4RrWstpZp2ouBKmtAnaMzna7mxTfJpeLHn22bhhMcHHKGma0pkoQMqNih9oUc06u15vkR5O2GohetOoPrXrRqvda597p_sXUjq77bH14nIGLHeBDH9No3mMaOl3MdoipT7MNnzX7-sd_DrWGtw</recordid><startdate>20170304</startdate><enddate>20170304</enddate><creator>Sahin, Yavuz</creator><creator>Özkaya, Enis</creator><creator>Kayatas Eser, Semra</creator><creator>Kutlu, Tayfun</creator><creator>Sanverdi, Ilhan</creator><creator>Tunali, Gulden</creator><creator>Karateke, Ates</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170304</creationdate><title>Serum substance P concentrations to predict oocyte maturation index and clinical pregnancy</title><author>Sahin, Yavuz ; Özkaya, Enis ; Kayatas Eser, Semra ; Kutlu, Tayfun ; Sanverdi, Ilhan ; Tunali, Gulden ; Karateke, Ates</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-a160a4cb564a62101a421cf7bf9446b634995c4671a25e93b38ece7845508c713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Assisted reproduction</topic><topic>Biomarkers - blood</topic><topic>Chorionic Gonadotropin - pharmacology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Hospitals, Teaching</topic><topic>Humans</topic><topic>implantation</topic><topic>In Vitro Oocyte Maturation Techniques</topic><topic>Infertility, Female - blood</topic><topic>Infertility, Female - therapy</topic><topic>Luteinizing Hormone - pharmacology</topic><topic>maturation index</topic><topic>Oocyte Retrieval</topic><topic>Oogenesis - drug effects</topic><topic>Ovulation Induction</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Pregnancy Tests</topic><topic>ROC Curve</topic><topic>Sperm Injections, Intracytoplasmic</topic><topic>substance P</topic><topic>Substance P - blood</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahin, Yavuz</creatorcontrib><creatorcontrib>Özkaya, Enis</creatorcontrib><creatorcontrib>Kayatas Eser, Semra</creatorcontrib><creatorcontrib>Kutlu, Tayfun</creatorcontrib><creatorcontrib>Sanverdi, Ilhan</creatorcontrib><creatorcontrib>Tunali, Gulden</creatorcontrib><creatorcontrib>Karateke, Ates</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecological endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahin, Yavuz</au><au>Özkaya, Enis</au><au>Kayatas Eser, Semra</au><au>Kutlu, Tayfun</au><au>Sanverdi, Ilhan</au><au>Tunali, Gulden</au><au>Karateke, Ates</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum substance P concentrations to predict oocyte maturation index and clinical pregnancy</atitle><jtitle>Gynecological endocrinology</jtitle><addtitle>Gynecol Endocrinol</addtitle><date>2017-03-04</date><risdate>2017</risdate><volume>33</volume><issue>3</issue><spage>203</spage><epage>207</epage><pages>203-207</pages><issn>0951-3590</issn><eissn>1473-0766</eissn><abstract>Aim: The aim of this study was to assess the predictive value of serum substance P (SP) concentrations on oocyte maturation and clinical pregnancy.
Methods: Ninety-three women with unexplained infertility underwent intracytoplasmic sperm injection (ICSI) cycles. Antagonist protocol was started for each participant and at the day of oocyte pick up, serum samples were obtained from each participant to assess SP concentrations, and these concentrations were utilized to predict mature/total oocyte ratio and clinical pregnancy.
Results: SP concentration was a significant predictor for mature/total oocyte ratio > 0.75 and clinical pregnancy. In correlation analyses, maturation index was significantly correlated with FSH (r= −0.226, p = 0.03), estradiol (r = 0.239, p = 0.021), peak estradiol (r = 0.414, p < 0.001), and substance P (r = 0.796, p < 0.001). In multivariate analyses, number of immature (beta coefficient = −0.379, p < 0.001), mature oocyte (beta coefficient = 0.473, p < 0.001), SP concentration (beta coefficient = 0.723, p < 0.001) and maturation index (beta coefficient = −0.387, p = 0.003) were significantly associated with clinical pregnancy.
Conclusion: SP concentrations at the day of oocyte pick up may be used to predict clinical pregnancy and may be an indirect indicator for cycle outcome in assisted reproductive technology (ART).</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>27908224</pmid><doi>10.1080/09513590.2016.1254611</doi><tpages>5</tpages></addata></record> |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adult Assisted reproduction Biomarkers - blood Chorionic Gonadotropin - pharmacology Cross-Sectional Studies Female Hospitals, Teaching Humans implantation In Vitro Oocyte Maturation Techniques Infertility, Female - blood Infertility, Female - therapy Luteinizing Hormone - pharmacology maturation index Oocyte Retrieval Oogenesis - drug effects Ovulation Induction Predictive Value of Tests Pregnancy Pregnancy Rate Pregnancy Tests ROC Curve Sperm Injections, Intracytoplasmic substance P Substance P - blood Turkey |
| title | Serum substance P concentrations to predict oocyte maturation index and clinical pregnancy |
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