Comparison of abuse, suspected suicidal intent, and fatalities related to the 7-day buprenorphine transdermal patch versus other opioid analgesics in the National Poison Data System

Objective: Prescription opioid related abuse, suicide and death are significant public health problems. This study compares rates of poison center calls categorized as intentional abuse, suspected suicidal intent or fatality for the 7-day buprenorphine transdermal system/patch (BTDS) with other exte...

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Bibliographic Details
Published in:Postgraduate medicine 2017-01, Vol.129 (1), p.55-61
Main Authors: Coplan, Paul M, Sessler, Nelson E, Harikrishnan, Venkatesh, Singh, Richa, Perkel, Charles
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analgesics, Opioid - therapeutic use
Buprenorphine - adverse effects
Buprenorphine - therapeutic use
Buprenorphine transdermal patch
Cause of Death
Chronic Pain - drug therapy
Cohort Studies
Female
Humans
intentional abuse
Male
Middle Aged
National Poison Data System (NPDS)
Poison Control Centers - statistics & numerical data
Prescription Drug Misuse - mortality
Prescription Drug Misuse - statistics & numerical data
Retrospective Studies
Sex Factors
Suicide - statistics & numerical data
suspected suicidal intent
Transdermal Patch
United States
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Summary:Objective: Prescription opioid related abuse, suicide and death are significant public health problems. This study compares rates of poison center calls categorized as intentional abuse, suspected suicidal intent or fatality for the 7-day buprenorphine transdermal system/patch (BTDS) with other extended-release and long-acting (ER/LA) opioids indicated for chronic pain. Methods: Retrospective 24-month cohort study using National Poison Data System data from July 2012 through June 2014. BTDS was introduced in the United States in January 2011. Numbers and rates of calls of intentional abuse, suspected suicidal intent and fatalities were evaluated for BTDS, ER morphine, ER oxycodone, fentanyl patch, ER oxymorphone and methadone tablets/capsules, using prescription adjustment to account for community availability. Rate ratios (RR) and 95% confidence intervals (CI) were calculated. Results: Absolute numbers and prescription-adjusted rates of intentional abuse and suspected suicidal intent with BTDS were significantly lower (p 
ISSN:0032-5481
1941-9260
DOI:10.1080/00325481.2017.1269596