Malaria in HIV-Infected Children Receiving HIV Protease-Inhibitor- Compared with Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy, IMPAACT P1068s, Substudy to P1060

HIV and malaria geographically overlap. HIV protease inhibitors kill malaria parasites in vitro and in vivo, but further evaluation in clinical studies is needed. Thirty-one children from Malawi aged 4-62 months were followed every 3 months and at intercurrent illness visits for ≤47 months (Septembe...

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Published in:	PloS one 2016-12, Vol.11 (12), p.e0165140
Main Authors:	Hobbs, Charlotte V., Gabriel, Erin E., Kamthunzi, Portia, Tegha, Gerald, Tauzie, Jean, Petzold, Elizabeth, Barlow-Mosha, Linda, Chi, Benjamin H., Li, Yonghua, Ilmet, Tiina, Kirmse, Brian, Neal, Jillian, Parikh, Sunil, Deygoo, Nagamah, Jean Philippe, Patrick, Mofenson, Lynne, Prescott, William, Chen, Jingyang, Musoke, Philippa, Palumbo, Paul, Duffy, Patrick E., Borkowsky, William
Format:	Article
Language:	English
Subjects:	Acquired immune deficiency syndrome AIDS Antimalarials - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Biology and Life Sciences CD4 Lymphocyte Count Child Child, Preschool Children Coinfection Comparative analysis Complications and side effects Demographic aspects Drug Therapy, Combination Female Genetic aspects Health risks Highly active antiretroviral therapy HIV HIV infections HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV Protease Inhibitors - therapeutic use HIV-1 - drug effects HIV-1 - enzymology HIV-1 - growth & development Human immunodeficiency virus Humans In vivo methods and tests Infant Lamivudine Lamivudine - therapeutic use Lentivirus Lopinavir Lopinavir - therapeutic use Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Malawi Male Medical diagnosis Medicine and Health Sciences Microscopy Nevirapine Nevirapine - therapeutic use Nucleosides Optimization Parasites People and Places Physiological aspects Plasmodium falciparum - drug effects Plasmodium falciparum - growth & development Protease Protease inhibitors Proteinase inhibitors Retroviridae Reverse Transcriptase Inhibitors - therapeutic use Risk factors Ritonavir Ritonavir - therapeutic use RNA-directed DNA polymerase Smear Therapy Vector-borne diseases Viral Load - drug effects Zidovudine Zidovudine - therapeutic use
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