Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance

Epicatechin (EC) intake has been suggested to be beneficial for the prevention of cardiovascular disorders, and it is well known that adipose tissue inflammation is one of the major risk factors for coronary heart diseases. The purpose of the present study was to determine the in vitro and in vivo e...

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Published in:	Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2017-03, Vol.27 (3), p.249-259
Main Authors:	Sano, T., Nagayasu, S., Suzuki, S., Iwashita, M., Yamashita, A., Shinjo, T., Sanui, T., Kushiyama, A., Kanematsu, T., Asano, T., Nishimura, F.
Format:	Article
Language:	English
Subjects:	3T3-L1 Cells adipocytes Adipocytes - drug effects Adipocytes - metabolism Adipocyte–macrophage interaction Adipokine adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Animals Anti-Inflammatory Agents - pharmacology Cardiovascular catechin Catechin - pharmacology CCL19 chemokine CCL19 Chemokine CCL19 - genetics Chemokine CCL19 - metabolism coculture Coculture Techniques coronary disease Diet, High-Fat - adverse effects Disease Models, Animal Down-Regulation Epicatechin gene expression gene expression regulation genes high fat diet in vivo studies Inflammation Insulin Resistance ligands liver Macrophage Activation - drug effects macrophages Macrophages - drug effects Macrophages - metabolism metabolism Mice Mice, Inbred C57BL microarray technology obesity Obesity - etiology Obesity - genetics Obesity - metabolism Obesity - prevention & control Panniculitis - etiology Panniculitis - genetics Panniculitis - metabolism Panniculitis - prevention & control RAW 264.7 Cells risk factors Time Factors
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