EVALUATION OF CEFPODOXIME PROXETIL IN THE PEDIATRIC FIELD

Pharmacokinetic and clinical evaluation of cefpodoxime proxetil (CPDX-PR, CS-807) were performed in the field of pediatrics. The obtained results are summarized as follows. 1. Peak serum concentrations of CPDX upon single oral doses of 3.0mg/kg and 4.4mg/kg of CPDX-PR were 1.26-1.46μg/ml and 1.45μg/...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1989/07/25, Vol.42(7), pp.1505-1518
Main Authors: NIINO, KENJI, SATO, HAJIME, NARITA, AKIRA, NAKAZAWA, SHINICHI, SUZUKI, HIROYUKI, MATSUMOTO, KIMIKO, NAKAZAWA, SUSUMU
Format: Article
Language:Japanese
Subjects:
Acute Disease
Administration, Oral
Bacteria - drug effects
Bacterial Infections - drug therapy
Bacterial Infections - metabolism
Bacterial Infections - microbiology
Bronchitis - drug therapy
Bronchitis - metabolism
Bronchitis - microbiology
Cefpodoxime
Cefpodoxime Proxetil
Ceftizoxime - administration & dosage
Ceftizoxime - analogs & derivatives
Ceftizoxime - pharmacokinetics
Ceftizoxime - pharmacology
Ceftizoxime - therapeutic use
Chemical Phenomena
Chemistry
Child
Child, Preschool
Drug Evaluation
Drug Resistance, Microbial
Female
Humans
Infant
Male
Scarlet Fever - drug therapy
Scarlet Fever - metabolism
Scarlet Fever - microbiology
Tonsillitis - drug therapy
Tonsillitis - metabolism
Tonsillitis - microbiology
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Summary:Pharmacokinetic and clinical evaluation of cefpodoxime proxetil (CPDX-PR, CS-807) were performed in the field of pediatrics. The obtained results are summarized as follows. 1. Peak serum concentrations of CPDX upon single oral doses of 3.0mg/kg and 4.4mg/kg of CPDX-PR were 1.26-1.46μg/ml and 1.45μg/ml, respectively, achieved at 4 hours and 1 hour after administration. Urinary excretion rates for CPDX in the first 8 hours ranged between 28.1 and 30.2%. 2. Clinical efficacy rates for pediatric infections obtained at single dose levels ranging 3 to 6mg/kg were 97.5%, and that at a single dose of 1mg/kg were 90.9%. 3. Bacteriological effectiveness was determined in 45 strains identified in recent cases. Eradication rates for these bacteria at dose levels of 3 to 6mg/kg and 1mg/kg were 91.3% and 9.5%, respectively. 4. No side effect nor abnormal laboratory test data were found in any of the cases examined. From these results, CPDX-PR appeared to be a useful antibiotic agent in the field of pediatrics.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.42.1505