GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use to two Ebola patients, both of whom survived, and is currently in Phase 2 clinical development...

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Bibliographic Details
Published in:Scientific reports 2017-03, Vol.7 (1), p.43395, Article 43395
Main Authors: Lo, Michael K., Jordan, Robert, Arvey, Aaron, Sudhamsu, Jawahar, Shrivastava-Ranjan, Punya, Hotard, Anne L., Flint, Mike, McMullan, Laura K., Siegel, Dustin, Clarke, Michael O., Mackman, Richard L., Hui, Hon C., Perron, Michel, Ray, Adrian S., Cihlar, Tomas, Nichol, Stuart T., Spiropoulou, Christina F.
Format: Article
Language:English
Subjects:
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A549 Cells
Alanine - analogs & derivatives
Alanine - chemical synthesis
Alanine - metabolism
Alanine - pharmacology
Animals
Antiviral Agents - chemical synthesis
Antiviral Agents - metabolism
Antiviral Agents - pharmacology
Cell Line, Tumor
Chlorocebus aethiops
Ebolavirus - drug effects
Ebolavirus - enzymology
Ebolavirus - growth & development
Gene Expression
HEK293 Cells
HeLa Cells
Hepatocytes - drug effects
Hepatocytes - virology
Humanities and Social Sciences
Humans
Marburgvirus - drug effects
Marburgvirus - enzymology
Marburgvirus - growth & development
Microbial Sensitivity Tests
multidisciplinary
Nucleosides - chemical synthesis
Nucleosides - metabolism
Nucleosides - pharmacology
Paramyxoviridae - drug effects
Paramyxoviridae - enzymology
Paramyxoviridae - growth & development
Pneumovirinae - drug effects
Pneumovirinae - enzymology
Pneumovirinae - growth & development
Prodrugs - chemical synthesis
Prodrugs - metabolism
Prodrugs - pharmacology
Ribonucleotides - chemical synthesis
Ribonucleotides - metabolism
Ribonucleotides - pharmacology
RNA Replicase - antagonists & inhibitors
RNA Replicase - chemistry
RNA Replicase - genetics
RNA Replicase - metabolism
Science
Vero Cells
Viral Proteins - antagonists & inhibitors
Viral Proteins - chemistry
Viral Proteins - genetics
Viral Proteins - metabolism
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