Alternative splicing: the pledge, the turn, and the prestige: The key role of alternative splicing in human biological systems

Alternative pre-mRNA splicing is a tightly controlled process conducted by the spliceosome, with the assistance of several regulators, resulting in the expression of different transcript isoforms from the same gene and increasing both transcriptome and proteome complexity. The differences between al...

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Bibliographic Details
Published in:Human genetics 2017-09, Vol.136 (9), p.1015-1042
Main Authors: Gallego-Paez, L. M., Bordone, M. C., Leote, A. C., Saraiva-Agostinho, N., Ascensão-Ferreira, M., Barbosa-Morais, N. L.
Format: Article
Language:English
Subjects:
Alternative Splicing
Biomedical and Life Sciences
Biomedicine
Developmental stages
Eukaryotes
Gene expression
Gene Function
Human Genetics
Humans
Isoforms
Localization
Metabolic Diseases
Microbiota
Molecular Medicine
Neurodevelopment
Precision medicine
Proteomes
Review
RNA Processing
RNA, Messenger - genetics
RNA, Messenger - metabolism
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