hSSB1 associates with and promotes stability of the BLM helicase

Background Maintenance of genome stability is critical in human cells. Mutations in or loss of genome stability pathways can lead to a number of pathologies including cancer. hSSB1 is a critical DNA repair protein functioning in the repair and signalling of stalled DNA replication forks, double stra...

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Bibliographic Details
Published in:BMC molecular biology 2017-05, Vol.18 (1), p.13, Article 13
Main Authors: Croft, Laura V., Ashton, Nicholas W., Paquet, Nicolas, Bolderson, Emma, O’Byrne, Kenneth J., Richard, Derek J.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
BLM protein
Cancer
Cell Biology
Cell cycle
Cell Line, Tumor
Chromatin
Chromatin - genetics
Chromatin - metabolism
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA Damage
DNA helicase
DNA Repair
DNA Replication
DNA replication and genome stability
Genomes
Homologous recombination
Humans
Hydroxyurea
I.R. radiation
Life Sciences
Nucleic Acid Chemistry
Plasmids
Polypeptides
Proteasome Endopeptidase Complex - metabolism
Proteasomes
Protein Binding
Protein deficiency
Protein Stability
Proteins
Proteolysis
RecQ Helicases - metabolism
Replication forks
Research Article
Signal transduction
Stress, Physiological
Suppressor of Cytokine Signaling Proteins - metabolism
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