Methods for molecular imaging of brain tumours in a hybrid MR-PET context: Water content, T 2 ∗ , diffusion indices and FET-PET

• Published in: Methods (San Diego, Calif.) Calif.), 2017-11, Vol.130, p.135
• Main Authors: Oros-Peusquens, A M, Loução, R, Zimmermann, M, Langen, K-J, Shah, N J
• Format: Article
• Language: English
• Subjects: Animals; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - metabolism; Diffusion; Humans; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - trends; Molecular Imaging - methods; Molecular Imaging - trends; Positron-Emission Tomography - methods; Positron-Emission Tomography - trends; Tyrosine - administration & dosage; Tyrosine - analogs & derivatives; Tyrosine - metabolism; Water - metabolism
• ISSN: 1095-9130
• DOI: 10.1016/j.ymeth.2017.07.025

The aim of this study is to present and evaluate a multiparametric and multi-modality imaging protocol applied to brain tumours and investigate correlations between these different imaging measures. In particular, we describe a method for rapid, non-invasive, quantitative imaging of water content of brain tissue, based on a single multiple-echo gradient-echo (mGRE) acquisition. We include in the processing a method for noise reduction of the multi-contrast data based on Principal Component Analysis (PCA). Noise reduction is a key ingredient to obtaining high-precision water content and transverse relaxation T values. The quantitative method is applied to brain tumour patients in a hybrid MR-PET environment. Active tumour tissue is identified by means of FET-PET; oedema, white and grey-matter segmentation is performed based on MRI contrasts. Water content information is not only relevant by itself, but also as a basis for correlations with other quantitative measures of water behaviour in tissue and interpreting the microenvironment of water. Water content in active tumour tissue (84%) and oedema (79%) regions is found to be higher than that of normal WM (69%) and close to that of normal GM (83%). Consistent with literature reports, mean kurtosis is measured to be lower in tumour and oedema regions than in normal WM and GM, whereas mean diffusivity is increased. Voxel-based correlations between water content and diffusion indices obtained with diffusion kurtosis tensor imaging, and between quantitative MRI and FET-PET are reported for 8 brain tumour patients. The effective transverse relaxation time T is found to be the MR parameter showing the strongest correlations with other MR indices derived here and with FET-PET.