Thymic Atrophy: Experimental Studies and Therapeutic Interventions

The thymus is essential for T cell development and maturation. It is extremely sensitive to atrophy, wherein loss in cellularity of the thymus and/or disruption of the thymic architecture occur. This may lead to lower naïve T cell output and limited TCR diversity. Thymic atrophy is often associated...

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Bibliographic Details
Published in:Scandinavian journal of immunology 2018-01, Vol.87 (1), p.4-14
Main Authors: Majumdar, S., Nandi, D.
Format: Article
Language:English
Subjects:
Aging
Animals
Atrophy
Bone Marrow Transplantation - adverse effects
Cytokines - physiology
Dietary Supplements
Gene Rearrangement, T-Lymphocyte
Graft vs Host Disease - etiology
Humans
Interleukin 7
Interleukin-7 - therapeutic use
Keratinocyte growth factor
Leptin
Leptin - physiology
Lymphocytes
Lymphocytes T
Morbidity
Supplements
T cell receptors
T-Lymphocytes - physiology
Therapeutic applications
Thymus
Thymus Gland - pathology
Transplantation
Zinc - administration & dosage
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